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- W2359031166 abstract "Objective To study the influence of PDT combined with Hedyotis diffusa in vitro on the anti-proliferative effect of Wistar rat glioma cell line C6. Methods MTT assay, acridine orange (AO)/ethidium bromide(ED) fluorescent staining and flow cytometry(FCM) were used to investigate the influence on C6 cells growth, observe apoptosis, analyze cell cycle and ultrastructure changes after treated by PDT and Hedyotis diffusa in vitro. Results Hedyotis diffusa was effective in inhibiting the proliferation C6 cells and could block cells in G_(0)/G_(1) phases and induce cell apoptosis. These effects could be enhanced significantly by PDT(P0.01). The Hedyotis diffusa and PDT could all induce cell apoptosis.When they combined, the inductive effect for cell apoptosis became more obvious at 5.0μg/ml of Hedyotis diffusa after 12 hours. Conclusions PDT can enhance the antiproliferative effect of Wistar rat glioma cell line C6. The synergestic antiproliferative effect of Hedyotis diffusa and PDT may be the result of cell apoptosis induction." @default.
- W2359031166 created "2016-06-24" @default.
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- W2359031166 date "2005-01-01" @default.
- W2359031166 modified "2023-09-23" @default.
- W2359031166 title "Increasing Anti-tumor Effect of PDT Combining with Hedyotis diffusa on C6 Cells Line" @default.
- W2359031166 hasPublicationYear "2005" @default.
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