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- W2359031820 abstract "Objective To determine p53 gene-specific hypomethylation and polymorphisms of DNMT3B gene in peripheral blood of patients with arseniasis due to exposure to indoor unventilated coal stove and to explore the association between hypomethylation of p53,polymorphism of DNMT3B and Arseniasis due to indoor unventilated-stove coal usage in Guizhou.Methods The effect of indoor unventilated-stove coal usage on p53 gene-specific hypomethylation and polymorphisms of DNMT3B gene was investigated by case-control study.MS-RE-PCR and PCR-RFLT were respectively performed to analyze p53 exon5 hypomethylation and polymorphisms of C46359T in DNMT3B promoter in arsenism patients group and control group.Results The positive rate of p53 gene hypomethylation in patients group was obviously higher than that in control group(P0.01).There was no statistical significance of p53 gene hypormethylaton rate among mild,intermediate and severe arseniasis groups by trend chi-square test(P0.05).In arsenism patients group,genotypic frequencies were 4.89%(CT),95.11%(TT)and 0(CC).In control group,genotypic frequencies were 4.76%(CT),95.24%(TT)and 0(CC)without showing statistical significance between two groups(P0.05).Compared to C/T,the T/T genotype did not significantly modify the risk of developing of Arseniasis(the age and gender adjusted OR=1.138,95% CI=0.309-4.198,the age and gender P=0.846).In control group of Guizhou in China,genotypic frequencies of 76%(CT),95.24%(TT)and 0(CC)were statistical significant(P0.01)comparing with the genotype frequencies of 41.8%(CT),23.2%(TT) 35.0%(CC)in Caucasian in USA and 45.0%(CT),23.3%(TT)31.8%(CC)in England.Conclusions Arsenic could probably induce hypomethylation of p53 gene exon 5;DNMT3B promoter C46359T SNP might not be used as a marker to predict susceptibility of Arseniasis caused by indoor unventilated-stove coal usage in Guizhou province." @default.
- W2359031820 created "2016-06-24" @default.
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- W2359031820 date "2013-01-01" @default.
- W2359031820 modified "2023-09-26" @default.
- W2359031820 title "Hypomethylation of p53 and polymorphism of DNMT3B in peripheral blood DNA associated with Arseniasis Produced by Indoor Unventilated-Stove Coal Usage" @default.
- W2359031820 hasPublicationYear "2013" @default.
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