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- W2359046063 abstract "Objective:To study the effect of luteinizing hormone (LH) on uterine development by investigating development-associated gene expression in LH receptor knockout mice.Methods:Analysis of uterine gene ex- pression on LH receptor knockout mice by gene microarray and RT-PCR.Results:The gene microarray revealed a differential expression of 155 genes by more than a-fold in the uterus between LH receptor knockout and wild- type mice.Ten genes decreased and 5 genes increased in the differential expression of development-associated gene.The cyclin D increased and cyclin B decreased in the expression of controlling cell cycle gene.Semi-quanti- tative RT-PCR confirmed the differential expression of several selected genes,revealing that cell cycle may be in- hibited.Twenty-one day estradiol and progesterone replacement therapy did not normalize the several genes ex- pression that either decreased or increased.Conclusion:The direct effect of LH or other factors on uterine func- tion may be required for normal uterine growth." @default.
- W2359046063 created "2016-06-24" @default.
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- W2359046063 date "2006-01-01" @default.
- W2359046063 modified "2023-09-25" @default.
- W2359046063 title "Effect of iuteinizing hormone on mice uterine development and development-associated gene expression" @default.
- W2359046063 hasPublicationYear "2006" @default.
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