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- W2359046402 abstract "Objective: To study the anti- oxidant activity of the different extracts on Lindera aggregata( Sims) Kosterm in acute alcoholic liver injury rats. Methods: 90 rats were divided into 9 groups. The same dosage of alcohol was given by gavage for 10 days to make a model of acute alcoholic injury. From the first day of model establishment,the rats in normal control group and model group were given water by gavage,and corresponding liquid were given in other groups,with dosage of 0. 5 g /100 g of the different extracts on Lindera aggregata( Sims) Kosterm. The blood and liver homogenate of rat was obtained to test the levels of ALT,AST,MDA and SOD. And the hepatocytic CYP2E1 mRNA expression was detected by real time PCR. Results: The levels of ALT,AST and MDA and expression of CYP2E1 mRNA were significantly increased in model group compared with that in normal control group,and decreased in treatment groups than that in model group. The levels of SOD were significantly decreased in model group compared with that in normal control group,and increased in treatment groups than that in model group. Conclusion: Lindera aggregata( Sims) Kosterm had protective anti-oxidant activity in acute alcoholic liver injury rats. Lindera aggregata( Sims) Kosterm can protect against the liver injury induced by acute ethanol administration and the mechanisms may be related to anti- oxidative stress as well as inhibiting the expression of CYP2E1 mRNA in rat liver." @default.
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- W2359046402 date "2014-01-01" @default.
- W2359046402 modified "2023-09-24" @default.
- W2359046402 title "Anti-oxidant Activity of Different Extracts on Lindera Aggregata(Sims)Kosterm in Acute Alcoholic Liver Injury Rats" @default.
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