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- W2359053225 abstract "Objective:To observe and analyze the impact of Yigan Jiangzhi Formula(YGJZF) in the pretreatment on the expression of endogenous protective substances inducible nitric oxide synthase(i NOS)m RNA and protein of alcoholic fatty liver SD rats and to explore YGJZF pretreatment simulation or strengthening the effect of ischemic preconditioning on liver protection mechanism. Method:116 SD rats were randomly divided into model group 22 and the Chinese intervention group 94. The model group was given fed high-fat diet and gastric perfusion of alcohol for 12 weeks to make AFL model and the Chinese intervention group added traditional Chinese medicine intervention on the basis of the model group. Completing the appropriate sampling slaughter at different times,we determined the contents of serum alanineaminotransferase(ALT),aspartate minotransferase(AST),triglyceride(TG),total cholesterol(T-CHO)in rats. Real-time quantitative(PCR)and Western blot were used to detect the expressions of i NOS m RNA and protein in rat liver and HE staining was used to observe rat liver tissue's patnological changes. Result:The levels of ALT,AST,TG and TC increased significantly in model group and compared with YGJZF medication three weeks,six weeks and nine weeks groups,the difference was statistically significant(P0.05). RT-PCR and Western blot displayed model group's liver tissue i NOS m RNA and protein expression gradually declined. HE staining of liver showed severe liver injury in model group with the extension of YGJZF medication time,the liver damage gradually reduced. Conclusion:The protection mechanism of YGJZF on alcoholic fatty liver may be triggering the endogenous protection conduction path of key material i NOS as well as simulating and strengthening the liver ischemic preconditioning effect." @default.
- W2359053225 created "2016-06-24" @default.
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- W2359053225 date "2015-01-01" @default.
- W2359053225 modified "2023-09-23" @default.
- W2359053225 title "Effects of Yigan Jiangzhi Formula in Pretreatment on Expression of Inducible Nitric Oxide Synthase of Alcoholic Fatty Liver SD Rats" @default.
- W2359053225 hasPublicationYear "2015" @default.
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