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- W2359087903 abstract "[Objective] To study the role of Caspase 8 and Caspase 3 in TRAIL-induced apoptosis of neuroblastoma cell line CHP212 cells. [Methods] The effects of TRAIL and Caspase 8/ Caspase 3 inhibitor+ TRAIL on the apoptosis of CHP212 cells were detected by flow cytometry. The relative Caspase 8/ Caspase 3 activity was measured by colorimetric assay. The Morphology of the apoptosis cells were detected by using the transmission electron microscope (TEM). [Results] TRAIL could induce apoptosis of CHP212 cells in a dose dependent way. Caspase 8/ Caspase 3 inhibitor could diminish the apoptosis of CHP212 cells induced by TRAIL. The relative Caspase 8/ Caspase 3 activity of CHP212 cells increased gradually with the prolongation of TRAIL action time and reached the peak at 16 h and 8 h respectively. Typical features of apoptosis were seen by TEM. [Conclusion] TRAIL could induce apoptosis of CHP212 cells through Caspase - transduced signal pathway with the increase of Caspase 8 and Caspase 3 activity." @default.
- W2359087903 created "2016-06-24" @default.
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- W2359087903 date "2008-01-01" @default.
- W2359087903 modified "2023-09-26" @default.
- W2359087903 title "Role of Caspase 8 and Caspase 3 in TRAIL-induced apoptosis of neuroblastoma cells" @default.
- W2359087903 hasPublicationYear "2008" @default.
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