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- W2359091168 abstract "Objective: To observe the effect of blocking notch signaling pathway on bone marrow mesenchymal stem cell( BMSC) proliferation and differentiation. Method: Established postmenopausal osteoporosis rat model first,and then BMSC were isolated for identification and cultivation. The rats were divided into shame group and DAPT group. observed BMSC proliferation and osteogenic differentiation of with MTT assay and the marker of ALP. Result: BMSC proliferation of both groups reached a peak value at the 9th day. OD values of DAPT group were lower than that of the control group from the 3rd day( n = 6,P 0. 05). The ALP expression of both groups reached a peak value at the 7th day. And at the 7th and 11 th day,the ALP expression of DAPT group were higher than control group( n = 6,P 0. 01). Conclusion: After blocking the notch pathway with DAPT,the BMSC proliferation of osteoporosis rat was inhibited,but the osteoblasts differentiation of BMSC was enhanced." @default.
- W2359091168 created "2016-06-24" @default.
- W2359091168 creator A5001766811 @default.
- W2359091168 date "2015-01-01" @default.
- W2359091168 modified "2023-09-26" @default.
- W2359091168 title "Effect of the Inhibition of BMSC Proliferation and Induce Osteogenic Differentiation in Ovariectomized Rats after Blocking Notch Signaling Pathway with DAPT" @default.
- W2359091168 hasPublicationYear "2015" @default.
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