Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359092507> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2359092507 abstract "Objective To explore the influence of leflunomide on Janus protein-tyrosine kinase(JAK)/signal transducer and activator of transcription(STAT) signal transduction pathway in renal tissue of MRL/lpr lupus mice.Methods Fourteen MRL/lpr mice were divided into control group and leflunomide group(35mg·kg-1·d-1 8 weeks).The expressions of phosphorylation of STAT1(p-STAT1) protein and SOCS-1 mRNA in renal tissue were detected and the changes in proteinuria,antibody of ds-DNA,histopathological variations and the deposition of immune complex(IC) in renal glomerule were observed.Results The amount of urinary protein and antibody of ds-DNA in leflunomide group were significantly lower than those in control group.The expressions of p-STAT1 protein and SOCS-1 mRNA in leflunomide group were significantly lower than those in control group.The histopathological changes were improved remarkably in leflunomide group.Conclusion Leflunomide can inhibit the expression of p-STAT1 and prevents the excess activation of JAK/STAT1 signal transduction pathway,which may be one of the mechanisms for the therapeutic effects in the MRL/lpr lupus mice." @default.
- W2359092507 created "2016-06-24" @default.
- W2359092507 creator A5003294979 @default.
- W2359092507 date "2009-01-01" @default.
- W2359092507 modified "2023-09-23" @default.
- W2359092507 title "Influence of leflunomide on JAK/STAT signal transduction pathway in renal tissue of MRL/lpr lupus mice" @default.
- W2359092507 hasPublicationYear "2009" @default.
- W2359092507 type Work @default.
- W2359092507 sameAs 2359092507 @default.
- W2359092507 citedByCount "0" @default.
- W2359092507 crossrefType "journal-article" @default.
- W2359092507 hasAuthorship W2359092507A5003294979 @default.
- W2359092507 hasConcept C112392421 @default.
- W2359092507 hasConcept C126322002 @default.
- W2359092507 hasConcept C134018914 @default.
- W2359092507 hasConcept C157333092 @default.
- W2359092507 hasConcept C171958077 @default.
- W2359092507 hasConcept C2775905006 @default.
- W2359092507 hasConcept C2776912625 @default.
- W2359092507 hasConcept C2777003663 @default.
- W2359092507 hasConcept C2777575956 @default.
- W2359092507 hasConcept C2778277574 @default.
- W2359092507 hasConcept C2778923194 @default.
- W2359092507 hasConcept C2779134260 @default.
- W2359092507 hasConcept C2779561371 @default.
- W2359092507 hasConcept C2780091579 @default.
- W2359092507 hasConcept C42362537 @default.
- W2359092507 hasConcept C502942594 @default.
- W2359092507 hasConcept C62478195 @default.
- W2359092507 hasConcept C71924100 @default.
- W2359092507 hasConcept C86803240 @default.
- W2359092507 hasConcept C95444343 @default.
- W2359092507 hasConceptScore W2359092507C112392421 @default.
- W2359092507 hasConceptScore W2359092507C126322002 @default.
- W2359092507 hasConceptScore W2359092507C134018914 @default.
- W2359092507 hasConceptScore W2359092507C157333092 @default.
- W2359092507 hasConceptScore W2359092507C171958077 @default.
- W2359092507 hasConceptScore W2359092507C2775905006 @default.
- W2359092507 hasConceptScore W2359092507C2776912625 @default.
- W2359092507 hasConceptScore W2359092507C2777003663 @default.
- W2359092507 hasConceptScore W2359092507C2777575956 @default.
- W2359092507 hasConceptScore W2359092507C2778277574 @default.
- W2359092507 hasConceptScore W2359092507C2778923194 @default.
- W2359092507 hasConceptScore W2359092507C2779134260 @default.
- W2359092507 hasConceptScore W2359092507C2779561371 @default.
- W2359092507 hasConceptScore W2359092507C2780091579 @default.
- W2359092507 hasConceptScore W2359092507C42362537 @default.
- W2359092507 hasConceptScore W2359092507C502942594 @default.
- W2359092507 hasConceptScore W2359092507C62478195 @default.
- W2359092507 hasConceptScore W2359092507C71924100 @default.
- W2359092507 hasConceptScore W2359092507C86803240 @default.
- W2359092507 hasConceptScore W2359092507C95444343 @default.
- W2359092507 hasLocation W23590925071 @default.
- W2359092507 hasOpenAccess W2359092507 @default.
- W2359092507 hasPrimaryLocation W23590925071 @default.
- W2359092507 hasRelatedWork W2067524667 @default.
- W2359092507 hasRelatedWork W2115027742 @default.
- W2359092507 hasRelatedWork W2350062759 @default.
- W2359092507 hasRelatedWork W2360551517 @default.
- W2359092507 hasRelatedWork W2368486396 @default.
- W2359092507 hasRelatedWork W2378309060 @default.
- W2359092507 hasRelatedWork W2388690559 @default.
- W2359092507 hasRelatedWork W2507319645 @default.
- W2359092507 hasRelatedWork W2760270300 @default.
- W2359092507 hasRelatedWork W2906114345 @default.
- W2359092507 hasRelatedWork W2912942100 @default.
- W2359092507 hasRelatedWork W2951625601 @default.
- W2359092507 hasRelatedWork W2981934626 @default.
- W2359092507 hasRelatedWork W3004218642 @default.
- W2359092507 hasRelatedWork W3005761690 @default.
- W2359092507 hasRelatedWork W3033644761 @default.
- W2359092507 hasRelatedWork W3125539156 @default.
- W2359092507 hasRelatedWork W3141025123 @default.
- W2359092507 hasRelatedWork W3167035630 @default.
- W2359092507 hasRelatedWork W245938639 @default.
- W2359092507 isParatext "false" @default.
- W2359092507 isRetracted "false" @default.
- W2359092507 magId "2359092507" @default.
- W2359092507 workType "article" @default.