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- W2359092593 abstract "Objective:To investigate olmesartan in reducing the intimal thickness by observing the remodeling of the vein transplanted from jugular to artery in rats. Methods: Forty-eight animal models were prepared by jugular vein graft and randomized into group of sham-operation,model controls,olmesartan administration and saline controls. Pathological ways were introduced to assess the intimal thickness of vessel walls and the change of the thickness was examined by vascular ultrasonography. Still,the variation of pulsatility index(PI) was verified in the 4 groups before and after administering olmesartan. Results: Intimal thickness of the grafted vein increased greatly in the model controls as compared with the sham-operation group,with increased PI(P0.01). In comparison with model controls,the growth of the transplanted vessel walls was checked evidently for the animals by intervention of olmesartan,with reduced PI(P0.05). Whereas no obvious change was observed in the saline controls as compared with the model controls and PI remained the same(P0.05). Ultrasonography could clearly expose the blood flow,diameter of the transplanted vessel and condition of the anastomosis. Conclusion: Olmesartan could be effective in remodeling the vessels in rats and improve the flexibility of transplanted veins. Ultrasonic testing could assess the function of vein graft." @default.
- W2359092593 created "2016-06-24" @default.
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- W2359092593 date "2009-01-01" @default.
- W2359092593 modified "2023-09-25" @default.
- W2359092593 title "Olmesartan in reducing intimal thickness of grafted vein in rats:assessment by vascular ultrasonography" @default.
- W2359092593 hasPublicationYear "2009" @default.
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