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- W2359094710 abstract "Objective:To study the effects of treadmill training on the recovery of neurological function and the expression of MMP-2 and VEGF in ischemic brain of rats after cerebral ischemia-reperfusion.Method: A total of thirty-five male adult Wistar rats were given cerebral ischemia-reperfusion and were randomly divided into sham-operated group,control group and exercise group,with treadmill running.Neurological function was measured at the 24h after the operation,the 3rd,the 7th and the 14th day after the beginning of exercise respectively.RT-PCR was used to detect the expression of MMP-2 and VEGF in the ischemic brain at the 3rd,7th and 14th day.Result:Compared with those in the control group,the behavior scores in exercise group was much lower at the 7th and 14th day(P0.05).MMP-2 expression in exercises group was higher than in the control group at the 7th and 14th day(P0.05).The expression of VEGF in the exercise group was greater than that in the control group at all points(P0.05).Conclusion:The expression of MMP-2 and VEGF in the brain ischemic area can be improved through treadmill training.It can promote recovery of neurological function by developing neurogenesis and promoting vascularization after cerebral infarction." @default.
- W2359094710 created "2016-06-24" @default.
- W2359094710 creator A5080668659 @default.
- W2359094710 date "2012-01-01" @default.
- W2359094710 modified "2023-09-27" @default.
- W2359094710 title "Effects of treadmill training on matrix metalloproteinases-2 and vascular endotheliar growth factor in ischemic brain of rats after cerebral ischemia-reperfusion" @default.
- W2359094710 hasPublicationYear "2012" @default.
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