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- W2359095026 abstract "Objective To study the relationship between angiogenesis and lymphangiogenesis with the expression of vascular endothelial growth factor C(VEGFC) and VEGFR-3 in human gastric carcinoma.Methods Samples of 56 gastric carcinoma cases with the neighboring noncancerous tissue were studied using anti-VEGFC,VEGFR-3 and CD34 antibodies.Assessment of lymphatic vessel density and microvessel density(MVD) were performed.Results ①The expression of VEGF-C in gastric carcinoma was significantly higher than that in control(73.2% vs 20.0% P0.01) Immunohistological staining with VEGF-C specific polyclonal antibody showed cytoplasmic and membranous staining in the cancer cells.②The positive expression of VEGFR-3 is chiefly located in cytomembrane and cytoplasm of cancer cells and vessel endothelial cel1s.③By spearman correlation analysis,We found that in cancer cells,VEGF-C expression correlated withVEGFR-3 expression(r=0.439,P0.05).④VEGF-C expression in gastric carcinoma were negatively associated with the differentiation of tumor cell(P0.05);The Positive expression of VEGF-C in cases that penetrate into muscle and serosa is significantly higher than that into mucosa and submucosa group(80.4% vs 40%,P0.05);the positive expression of VEGF-C in 1ymPh node metastasis group is higher than that in no 1ymph node metastasis group(82.9% vs 12.0%,P0.05);The expression of VEGFR-3 in cancer cell is associated with tumor size,infiltration depth and 1ymph node metastasis.Lymphatic vessel density is associated with tumor size,infiltration depth 1ymph node metastasis.⑤By Kaplan-Meier survival analysisan VEGF-C expression is found to be in dependent factors for Patients prognosis.Conclusion VEGF-C in gastric carcinoma.are related to lymphangiogenesis and angiogenesis,as well as to the occurrence and the development of gastric carcinoma.VEGF-C promotes intratumoral lymphangiogenesis via VEGFR-3,resulting facilitated invasion of cancer cells into the lymphatic vessels VEGF-C expression can be a useful predictor of poor prognosis in gastric carcimona." @default.
- W2359095026 created "2016-06-24" @default.
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- W2359095026 date "2007-01-01" @default.
- W2359095026 modified "2023-09-27" @default.
- W2359095026 title "Expression of Vascular Endothelial Growth Factor(VEGF) C and VEGF Receptor 3 in Gastric Carcinoma" @default.
- W2359095026 hasPublicationYear "2007" @default.
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