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- W2359100262 abstract "Objective: To investigate the changes of serum soluble intercellular adhesion molecule-1(sICAM-1) and interleukin-18(IL-18) in patients with type B hepatitis cirrhosis,and their relationship with HBV replication.Methods: Serum levels of sICAM-1 and IL-18 of 60 type B hepatitis cirrhosis patients(group A) and 30 normal persons(group B) were detected with enzyme linked immunosorbent assay(ELISA).The serum level of HBV-DNA in patients of group A was detected with fluorescent quantitative PCR.Results: The serum levels of sICAM-1 and IL-18 in group A were significantly higher than those in group B(P0.01).There was a positive correlation between serum levels of sICAM-1 and IL-18.There was no significant difference in serum levels of sICAM-1 between HBV-DNA positive group and HBV-DNA negative group in group A(P0.05),but there was significant difference in serum levels of IL-18 between them in group A(P0.01).Conclusions: The change of serum level of sICAM-1 in patients with type B hepatitis cirrhosis does not relate to replication of HBV.It suggests that secondary immune injury lead to the expression of sICAM-1,which results in injury of liver cells.Since change of IL-18 serum level in these patients relates to replication of HBV,measuring IL-18 level has some practical value in monitoring HBV replication and antiviral therapy application." @default.
- W2359100262 created "2016-06-24" @default.
- W2359100262 creator A5018585776 @default.
- W2359100262 date "2010-01-01" @default.
- W2359100262 modified "2023-09-24" @default.
- W2359100262 title "The Relation between HBV-DNA Replication and the Changing Levels of Serum sICAM-1 and IL-18 in Patients with Hepatitis B Cirrhosis" @default.
- W2359100262 hasPublicationYear "2010" @default.
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