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- W2359123929 abstract "Objective: To investigate the effect of Cvcas revolute Thunb extract(CTE) on apoptosis of tumor cell line,A549 cells,and the possible mechanism.Methods: A549 cells were incubated with different concentrations of CTE,and the inhibition of cell proliferation was determined by MTT assay.The CTE-induced apoptosis was observed by Gimsa staining,fluorescent staining,flow-cytometry(FCM),and DNA agarose gel electrophoresis.The mRNA expression of Bcl-2,Bax and caspase-3 was detected by RT-PCR.Results: CTE exhibited antiproliferative activity in dose-and time-dependent manners.After treatment with CTE,morphological examination showed typical apoptotic bodies.Agarose gel electrophoresis demonstrated a characteristic ladder-like pattern of DNA fragmentation.FCM showed subdiploid peaks before G0/G1 phase.The cells in G2-M phase were arrested and the apoptosis rate was 34.37%.CTE also up-regulated Bax mRNA expression;and down-regulated Bcl-2 and caspase-3 mRNA expression.Conclusion: CTE induces apoptosis of A549 cells,and the possible mechanism may be associated with the change of apoptosis-related gene expression in cancer cells." @default.
- W2359123929 created "2016-06-24" @default.
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- W2359123929 date "2008-01-01" @default.
- W2359123929 modified "2023-09-23" @default.
- W2359123929 title "Effect of Cvcas revolute Thunb extract on apoptosis of A549 cells and the possible mechanism" @default.
- W2359123929 hasPublicationYear "2008" @default.
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