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- W2359138982 abstract "Objective To study the plasma concentration of MMPs/TIMP in gastric cancer and their use as potential prognostic tumor markers. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma con- centration of MMPs/TIMP in patients with gastric cancer, patients with benjgn gastric disease and healthy volunteers. The correlation between ELISA results and clinical prognosis was studied in the three groups. Results !Plasma MMPs/TIMP were significantly increased in patients with gastric cancer , but not in patients with benign gastric disease and healthy volunteers. In patients with gastric cancer, the plasma levels of MMP-2, MMP-9 and TIMP-l were (21.7±6.3)ng/ml, (17.9± 9.2)ng/ml and (39.5±13.3)ng/ml, respectively. The plasma levels of MMP-2, MMP-9 and TIMP-1 were significanly different between patients with gastric carcinoma, especially those with Stage IV gastric cancer, and the healthy volunteers. Plasma MMP-2 expression demonstrated a positive association with depth of tumour invasion and metastasis. The concen- tration of TIMP-1 was related with metastasis. The expression of MMP-2 was also related with the survival time of gastric carcinoma patients. Conclusions The assay of plasma MMP-2 could be clinically useful in predicting prognosis in sub- sets of patients with gastric cancer." @default.
- W2359138982 created "2016-06-24" @default.
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- W2359138982 date "2005-01-01" @default.
- W2359138982 modified "2023-09-24" @default.
- W2359138982 title "Plasma assay of metalloproteinases and tissue inhibitor of metalloproteinase complexes in gastric cancer" @default.
- W2359138982 hasPublicationYear "2005" @default.
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