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- W2359145209 abstract "Objective To investigate the association between CYP11B2 gene polymorphism and essential hypertension in Chinese Han by the means of meta-analysis.Methods Literatures about case-control study on the association of CYP11B2 gene polymorphism and essential hypertension were searched from January 1980 to December 2010.The electronic databases retrieved from China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database and Pubmed.Odds ratio of CYP11B2 genotype distributions in essential hypertension patients against healthy control were analyzed.RevMan 4.2 software was applied for investigating hereogeneity among individual studies and aummarizing effects across studies by proper statistical methods.Twelve case-control studies were selected finally.Results A total of 3635 cases and 3134 controls were included.The pooled OR(95% CI)of CC vs TT+TC genotype was 1.08(0.81,1.43)(Z=0.52,P=0.60),and the pooled OR(95% CI)of C vs T allele was 1.14(0.92,1.40)(Z=1.20,P=0.23).Conclusion The genotype of CYP11B2 polymorphism is not associated with an increased risk of essential hypertension in Chinese Han population." @default.
- W2359145209 created "2016-06-24" @default.
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- W2359145209 date "2011-01-01" @default.
- W2359145209 modified "2023-09-28" @default.
- W2359145209 title "Meta analysis on the association of CYP11B2 gene polymorphism and essential hypertension in Chinese Han population" @default.
- W2359145209 hasPublicationYear "2011" @default.
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