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- W2359153117 abstract "The fusion protein of IL-6-PE40 which is composed of human interleukin 6 fused with mutant form of pseudomonas exotoxin (PE) devoid of its native cell recognition domain can kill tumor cells expressing high levels of IL-6 receptors. In the present study cytotoxic effect of IL-6-PE40 on granulopoiesis of bone marrow in normal BN rat was assessed and compared with effect of human IL-6 using granulocyte-macrophage colony forming unit (CFU-GM) and 3H-TdR incorporation assays. The fused protein of IL-6-PE40 is cytotoxic to U266, a human myeloma cell line expressing high levels of IL-6 receptors on the cell surface. The dose of IL-6-PE40 required to inhibit protein synthesis by 50% was 10ng/ml, while 1000ng/ml of IL-6-PE40 produced 100% inhibition of protein synthesis. In contrast, there was no obvious cytotoxic effect on CFU-GM growth and DNA synthesis in normal bone marrow at the dose range of 1-1000ng/ml of IL-6-PE40. On the other hand, rhIL-6 itself at a dose range of 1000U / ml to 4000U / ml was able to support moderately CFU-GM growth and DNA synthesis. These findings provide evidence that granulocyte-macrophage hematopoietic progenitors and bone marrow cells do not express IL-6 receptors on their surface and are not sensitive to IL-6-PE40 in vitro." @default.
- W2359153117 created "2016-06-24" @default.
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- W2359153117 date "1993-01-01" @default.
- W2359153117 modified "2023-09-25" @default.
- W2359153117 title "EFFECT OF RECOMBINANT INTERLEUKIN-6-PSEUDO- MONAS EXOTOXIN CHIMERIC PROTEIN (IL-6-PE40) ON IN VITRO GRANULOPOIESIS OF NORMAL BN RAT" @default.
- W2359153117 hasPublicationYear "1993" @default.
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