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- W2359153644 abstract "Objective Kaposiform hemangioendothelioma(KHE),a borderline tumor of endothelial origin,is associated with Kasabach-Merritt phenomenon,which is characterized by profound thrombocytopenia and consumptive coagulopathy.Previous studies have suggested that the trapping of platelets may underlie coagulopathy in KHE.However,more evidence is needed to support this hypothesis.Methods We collected samples of KHE complicated by Kasabach-Merritt phenomenon in one Chinese infant,conducted ultrastructural observation,performed immunohistochemical staining of Glut1,and analyzed the distribution of erythrocytes.Infantile hemangiomas without Kasabach-Merritt phenomenon were used as the control.Results Ultrastructural analysis revealed the trapping of platelets,macrophages and lymphocytes in the slit-like channels of tumor nodules,and phagocytic vesicles in the cytoplasm of neoplastic cells.Immunohistochemical staining of Glut1 showed many erythrocytes in the slit-like channels.No blood components were seen in the microvessels in infantile hemangiomas.Conclusion Our results provided compelling morphological evidence for the trapping of blood components in KHE." @default.
- W2359153644 created "2016-06-24" @default.
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- W2359153644 date "2012-01-01" @default.
- W2359153644 modified "2023-09-25" @default.
- W2359153644 title "Trapping of blood components in kaposiform hemangioendothelioma" @default.
- W2359153644 hasPublicationYear "2012" @default.
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