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- W2359153981 abstract "Objective To examine the effect of potassium channel opener NS1619 on the rats with allergic asthma provoked with ovalbumin(OVA).Methods The allergic asthma was provoked with(OVA).The rats with allergic asthma were devided into five groups,including control group,asthma group,NS1619 group,dexamethasone group and saline group.Asthma group was provoked with OVA to induced asthma,and control group was as control.NS1619 group,dexamethasone group and saline group were inhaled NS1619,dexamethasone and saline,respectively,after provoking with OVA to induced asthma.The latency period of symptom after induced asthma was compared.The cells in bronchial alveolarlavage fluid(BALF)were counted and classified.Results The latency period of NS1619 group and dexamethasone group were longer than that of saline group(P0.05).In lung tissue stained with HE,it demonstrated bronchiospasm,massive phlegmasia cells and eosinophile granulocyte infiltration in submucosa.In NS1619 group,total BALF score and the percentage of eosinophile granulocyte,lymphocyte were much less than that of saline group(P0.01).Conclusions Selective potassium channel activator NS1619 not only decreases airway resistance but also inhibit airway inflammation." @default.
- W2359153981 created "2016-06-24" @default.
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- W2359153981 date "2008-01-01" @default.
- W2359153981 modified "2023-09-28" @default.
- W2359153981 title "The Effect of NS1619 on rats with allergic asthma" @default.
- W2359153981 hasPublicationYear "2008" @default.
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