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- W2359167193 abstract "Objective:To study the antibiotic such as amoxicillin,clarithromycin and levofloxacin and so on rabeprazole pharmacokinetics in rabbits effect for combination therapy to provide more reasonable basis.Methods:Six rabbits were first duodenal intubation under the Department for H.10cm,catheter back through a subcutaneous tunnel fixed to the skin.Different time points after administration of blood,high performance liquid chromatography plasma concentration,pharmacokinetic analysis of line.After each administration method were to be 1 week washout period.Time point of blood administration 0min,lmin,3min,6min,10min,15min,30min,45min,lh,1.5h,each point blood 2ml.Results:The pharmacokinetic parameters between the AUC(0-∞)(mg / L * h),Tl/2z(h),Tmax(h),CLz(L / h / kg) and Cmax(mg / L) by statistical analysis of rabeprazole and rabeprazole combined with amoxicillin and amoxicillin,clarithromycin pharmacokinetic parameters when combined with rabeprazole alone was no significant difference when,rabeprazole and combination of clarithromycin and rabeprazole in combination with levofloxacin AUC(0-∞)(mg / L * h) compared with a time of rabeprazole alone increased,but no significant difference,other pharmacokinetic parameters no significant change.Conclusion:Thus,rabeprazole combined with antibiotic treatment for Hp eradication of antibiotics on the pharmacokinetics of rabeprazole had no effect,indicating that antibiotic pharmacodynamics rabeprazole could not influence." @default.
- W2359167193 created "2016-06-24" @default.
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- W2359167193 date "2010-01-01" @default.
- W2359167193 modified "2023-09-25" @default.
- W2359167193 title "Study on Pharmacokinetics of Combined on Rabeprazole" @default.
- W2359167193 hasPublicationYear "2010" @default.
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