Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359175556> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2359175556 endingPage "62" @default.
- W2359175556 startingPage "857" @default.
- W2359175556 abstract "To investigate the role of calcineurin (CaN) in the lung fibroblast proliferation and collagen synthesis induced by basic fibroblast growth factor (bFGF).We used Western blot and immunohistochemical methods for investigating the content and distribution of calcineurin in the lung tissue. Calcineurin activity in different tissues was measured using (32)P-labelled substrate. In the primary culture of lung fibroblasts, (3)H-thymidine ((3)H-TdR) and (3)H-proline incorporation methods were used to study the effect of cyclosporin A (CsA), an inhibitor of calcineurin, on the lung fibroblast DNA and collagen synthesis stimulated by bFGF.We found that calcineurin was expressed in lung tissue and has phosphatase activity (7.1 +/- 2.0 pmol Pi/mg pr/min). CsA (10(-8) - 10(-6) mol/L) inhibited lung fibroblast (3)H-TdR incorporation induced by bFGF in a dose-dependent manner, with the inhibitory rates by 20%, 46% and 66% (P < 0.01). CsA (10(-7) - 10(-6) mol/L) inhibited (3)H-proline incorporation in lung fibroblasts stimulated by bFGF, with the inhibitory rates by 21% and 37% (P < 0.01). In a culture medium, CsA (10(-8) - 10(-6) mol/L) inhibited (3)H-proline secretion induced by bFGF in a dose-dependent manner, with the inhibitory rates by 19%, 29% (P < 0.05) and 56% (P < 0.01). CsA (10(-7) mol/L) could inhibit calcineurin activity by 44% in lung fibroblasts (P < 0.01).Calcineurin is expressed in lung tissue and has phosphatase activity. It is involved in the bFGF stimulated lung fibroblast DNA and collagen synthesis." @default.
- W2359175556 created "2016-06-24" @default.
- W2359175556 creator A5023687518 @default.
- W2359175556 creator A5026966223 @default.
- W2359175556 creator A5034060293 @default.
- W2359175556 creator A5042433380 @default.
- W2359175556 creator A5046080439 @default.
- W2359175556 date "2003-06-01" @default.
- W2359175556 modified "2023-09-23" @default.
- W2359175556 title "The role of calcineurin in the lung fibroblasts proliferation and collagen synthesis induced by basic fibroblast growth factor." @default.
- W2359175556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12877795" @default.
- W2359175556 hasPublicationYear "2003" @default.
- W2359175556 type Work @default.
- W2359175556 sameAs 2359175556 @default.
- W2359175556 citedByCount "4" @default.
- W2359175556 countsByYear W23591755562015 @default.
- W2359175556 countsByYear W23591755562019 @default.
- W2359175556 countsByYear W23591755562022 @default.
- W2359175556 crossrefType "journal-article" @default.
- W2359175556 hasAuthorship W2359175556A5023687518 @default.
- W2359175556 hasAuthorship W2359175556A5026966223 @default.
- W2359175556 hasAuthorship W2359175556A5034060293 @default.
- W2359175556 hasAuthorship W2359175556A5042433380 @default.
- W2359175556 hasAuthorship W2359175556A5046080439 @default.
- W2359175556 hasConcept C104317684 @default.
- W2359175556 hasConcept C126322002 @default.
- W2359175556 hasConcept C128057223 @default.
- W2359175556 hasConcept C134018914 @default.
- W2359175556 hasConcept C153911025 @default.
- W2359175556 hasConcept C170493617 @default.
- W2359175556 hasConcept C185592680 @default.
- W2359175556 hasConcept C202751555 @default.
- W2359175556 hasConcept C2775960820 @default.
- W2359175556 hasConcept C2776415932 @default.
- W2359175556 hasConcept C2777587049 @default.
- W2359175556 hasConcept C2777714996 @default.
- W2359175556 hasConcept C2780381497 @default.
- W2359175556 hasConcept C2911091166 @default.
- W2359175556 hasConcept C55493867 @default.
- W2359175556 hasConcept C64241487 @default.
- W2359175556 hasConcept C71924100 @default.
- W2359175556 hasConcept C86803240 @default.
- W2359175556 hasConceptScore W2359175556C104317684 @default.
- W2359175556 hasConceptScore W2359175556C126322002 @default.
- W2359175556 hasConceptScore W2359175556C128057223 @default.
- W2359175556 hasConceptScore W2359175556C134018914 @default.
- W2359175556 hasConceptScore W2359175556C153911025 @default.
- W2359175556 hasConceptScore W2359175556C170493617 @default.
- W2359175556 hasConceptScore W2359175556C185592680 @default.
- W2359175556 hasConceptScore W2359175556C202751555 @default.
- W2359175556 hasConceptScore W2359175556C2775960820 @default.
- W2359175556 hasConceptScore W2359175556C2776415932 @default.
- W2359175556 hasConceptScore W2359175556C2777587049 @default.
- W2359175556 hasConceptScore W2359175556C2777714996 @default.
- W2359175556 hasConceptScore W2359175556C2780381497 @default.
- W2359175556 hasConceptScore W2359175556C2911091166 @default.
- W2359175556 hasConceptScore W2359175556C55493867 @default.
- W2359175556 hasConceptScore W2359175556C64241487 @default.
- W2359175556 hasConceptScore W2359175556C71924100 @default.
- W2359175556 hasConceptScore W2359175556C86803240 @default.
- W2359175556 hasIssue "6" @default.
- W2359175556 hasLocation W23591755561 @default.
- W2359175556 hasOpenAccess W2359175556 @default.
- W2359175556 hasPrimaryLocation W23591755561 @default.
- W2359175556 hasRelatedWork W1981791036 @default.
- W2359175556 hasRelatedWork W1987138866 @default.
- W2359175556 hasRelatedWork W1998783289 @default.
- W2359175556 hasRelatedWork W2024971094 @default.
- W2359175556 hasRelatedWork W2053442975 @default.
- W2359175556 hasRelatedWork W2074553603 @default.
- W2359175556 hasRelatedWork W2095264862 @default.
- W2359175556 hasRelatedWork W2164426283 @default.
- W2359175556 hasRelatedWork W2359175556 @default.
- W2359175556 hasRelatedWork W83033334 @default.
- W2359175556 hasVolume "116" @default.
- W2359175556 isParatext "false" @default.
- W2359175556 isRetracted "false" @default.
- W2359175556 magId "2359175556" @default.
- W2359175556 workType "article" @default.