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- W2359175959 abstract "Objective To investigate the relationship between contractive activity of isolated proximal colon smooth muscle and the change of somatostatin(SS),vasoactive intestinal peptide(VIP),motilin(MTL),substance P(SP) in diabetes mellitus rats.Methods Twenty male Sprague-Dawley rats were divided into two groups:the control(n=10) and the experimental(n=10).The resting tension,the mean contractile amplitude and frequency of spontaneous changes of isolated longitudinal,circular proximal colon smooth muscle strips were measured by transducer,and SS,VIP,MTL,SP levels in plasma and proximal colon tissue extracts were measured by radioimmunoassay.Results (1)In isolated colon smooth muscle strips,the motility parameters were significantly lower in diabetic rats than those in control(P0.01).(2)In diabetic rats,the plasma levels of SS,VIP and MTL were higher than those in control(P0.05),while SP level was decreased(P0.05).In the proximal colon,the levels of SS,VIP were significantly lower than in the control(P0.05),the level of SP was higher than that of the control(P0.05),and the level of MTL did not differ from that in the lean control(P0.05).(3)In diabetic rats,there was no excellent correlation between the plasma,tissue SS levels and the motility parameters of colon,and the plasma VIP and MTL had a negative correlation with the motility parameters of colon,but the VIP level of proximal colon had a positive correlation with colon motility parameters.The plasma SP level had a positive correlation with colon motility.Conclusions (1)Diabetic rats have colonic dysfunction and it is related with the disturbed neuroendocrine peptides.(2)The changes of these peptideslevels in plasma and colon tissue may play some role in the gastrointestinal disorders of diabetes mellitus." @default.
- W2359175959 created "2016-06-24" @default.
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- W2359175959 date "2003-01-01" @default.
- W2359175959 modified "2023-09-23" @default.
- W2359175959 title "Research on neuroendocrine peptides and gastrointestinal dysmotility in diabetes mellitus" @default.
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