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- W2359196108 abstract "Objective To systematically review the efficacy and safety of sitagliptin for type 2 diabetes mellitus. Methods Randomized controlled trials( RCTs) were retrieved from the Cochrane Library,Pub Med,EMBASE,CBM,VIP and CNKI. We used the method recommended by the Cochrane Collaboration to perform a meta-analysis of RCTs. Results Altogether 20 studies were included. The meta-analysis showed that sitagliptin provided greater reductions in Hb A1 c than α-glycosidase inhibitors. In weight control,sitagliptin showed greater reductions compared with sulfonylureas,thiazolidinedione and insulin. Lower incidence of overall adverse events( AEs) was observed in Sitagliptin than in metformin,sulfonylureas,α-glycosidase and glucagon like peptide-1( GLP-1) receptor agonist. The incidence of hypoglycemia in sitagliptin,metformin,sulfonylureas,voglibose and GLP-1 receptor agonist had no statistically significant difference. Conclusion Sitagliptin is effective and safe for type 2 diabetes." @default.
- W2359196108 created "2016-06-24" @default.
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- W2359196108 date "2015-01-01" @default.
- W2359196108 modified "2023-09-25" @default.
- W2359196108 title "A Meta-analysis on Sitagliptin and Other Antidiabetic Drugs in the Treatment of Type 2 Diabetes" @default.
- W2359196108 hasPublicationYear "2015" @default.
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