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- W2359199411 abstract "AIM: To investigate the value of integrin α3 and αM subunits as the markers of hepatic fibrosis in patients with hepatitis C virus (HCV) and post inflammatory liver cirrhosis by determining their localization and expression levels in the cirrhotic liver after HCV infection. METHODS: With informed consent, 3 normal liver graft tissues and 12 liver tissues with post HCV inflammatory cirrhosis were obtained during operation. The cirrhotic liver tissues were divided into 2 groups: α3 and αM group, in which 8 patients were at Child A class, 2 at class B and 2 at class C. Immunohistochemistry was used to compare the expression levels and locations of α3 with those of αM. (RESULTS:) No α3 and αM positive cells were found in normal liver tissues. The expression level of αM was higher than that of α3 significantly (P0.05). In cirrhotic liver, the newly-formed basement membranes (BM) were associated with the positive expression of integrin α3 on the surfaces of the hepatocytes and sinusoidal epithelial cells (SECs). The integrin α3 was mainly located around the central vein and αM positive areas were distributed around central vein and portal area. No significant differences between Child classification A, B and C were found in α3 and αM expression. CONCLUSION: Integrin α3 and αM subunits are involved in the development of capillarized sinusoids and play an important role in the initiation of liver cirrhosis. αM subunits can be used as a useful index in clinical tests." @default.
- W2359199411 created "2016-06-24" @default.
- W2359199411 creator A5003889190 @default.
- W2359199411 date "2005-01-01" @default.
- W2359199411 modified "2023-09-24" @default.
- W2359199411 title "Localization and expression level of integrin subunits α3 and αM in human cirrhotic liver" @default.
- W2359199411 hasPublicationYear "2005" @default.
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