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- W2359200645 abstract "Objective To observe the preanaesthetic effects and safety of penehyclidine hydrochloride(PH) for general anaesthesia in pedo-ocular trauma surgery.Methods 40 pedo-ocular trauma patients undergoing surgery with general anaesthesia were divided into two groups A and B randomly.Group A(n=20) was given 0.01mg/kg atropine iv.While group B (n=20) was given 0.01mg/kg PH iv.Signed each patient's PR before induction of anaesthesia,after 10 min,20 min and 40 min of administration of the drug and monitored the change in heart rate and blood pressure,facial color before and after the administration of the drug,degree of dry mouth,nasopharyngeal temperature(NTP),degree of sedation and the upper respiratory tract secretion of the patients at these 4 time intervals.Results The SBP and DBP before and after drug administration didn't have contrast change(P0.05) comparatively in either groups.In group A,the HR comparatively increased after 10 and 20 min of drug administration(P0.05),the HR change after 40 min of drug administration was not obvious(P0.05).In group B,there was no obvious change in HR in the above given time intervals(P0.05).Red coloring of the face during the given time intervals was obvious in group A but not in group B.Dryness of mouth within 20 min of administration of drug in comparison with before administration was obvious in group A(P0.05),but not after 40 min of drug administration(P0.05).There was obvious dryness of mouth in group B within the above given time(P0.05).In group B,there was no obvious change in body temperature at the above given time(P0.05): there was obvious change in body temperature in group A at 10 min and 20 min of drug administration(P0.01),after 40 min of drug administration the body temperature was close to that of before the administration of drug.There was no sedative effect at given time intervals after drug administration in group A patients,but there were 5 types of sedative effects in group B after drug administration.Conclusions PH has low effect in HR,facial color and body temperature change than do atropine.PH has a little sedating effect and it's anticholinesterase effect is longer than that of atropine.PH can more effectively control the respiratory tract secretion of the patients under general anaesthesia which ensures the safety of general anaesthesia in pedo-ocular trauma surgery." @default.
- W2359200645 created "2016-06-24" @default.
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- W2359200645 date "2006-01-01" @default.
- W2359200645 modified "2023-09-24" @default.
- W2359200645 title "Preaneanesthetic effect of penehyclidine hydrochloride in pediatric ocular trauma surgery with general anesthesia" @default.
- W2359200645 hasPublicationYear "2006" @default.
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