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- W2359201349 abstract "Objective To study the expression and location of vascular endothelial growth factor(VEGF)and VEGFR2 in the epididymis of experimental left varicocele(ELV)rats and explore the effect of both proteins in male infertility caused by varicocele.Methods ELV models of rats were established by partial ligation of the left renal vein.The epididymis was collected at 2 and 4 weeks after the operation.The VEGF and VEGFR2 expression changes were observed by immunohistochemistry.Results Immunohistochemistry results showed a notable increase of VEGF protein expression in 2-and 4-week ELV groups compared with that in the corresponding control groups,and VEGF expression in ELV 4 week groups was lower than that in ELV 2-week groups.There was a remarkable increase of VEGFR2 protein expression in ELV 2-week groups compared with that in the corresponding control groups.However,in ELV 4-week groups,VEGFR2 expression was remarkably decreased compared with that in both control and ELV 2-week groups.Conclusion ELV affects the expression of both VEGF and VEGFR2 in epididymis of rats.It indicates that VEGF and VEGFR2 may play an important role in male infertility caused by varicocele." @default.
- W2359201349 created "2016-06-24" @default.
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- W2359201349 date "2009-01-01" @default.
- W2359201349 modified "2023-09-23" @default.
- W2359201349 title "Effects of experimental left varicocele on the expression of VEGF and VEGFR2 proteins in the epididymis of adolescent rats" @default.
- W2359201349 hasPublicationYear "2009" @default.
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