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- W2359208523 abstract "Objective: To investigate the effects of dietary contain puerarin on the cardiometabolic indexes on obesity-hyp-ertension rats,especially the blood pressure and the vascular fuction.Methods: Eight weeks old Spontaneously Hypertensive Rats were divided into three groups-the control group,give the normal chow,high fat diet group,give the high fat diet,the high fat diet and the puerarin group,give the high fat diet contain 0.1% puerarin,each group has eight rats,and the intervention time is 14 weeks.The tail blood pressure and the body weight were detected every week.And at the end of the study,the rats were fasting for 12hrs and the blood sample was took to detected the fasting blood glucose and lipids levels.Lastly the endothelium-dependent and the endothelium-independent relaxation of the aorta were detected by wire myograph.Results: The high fats diet increased the body weight which lead to obesity,rise the lipids levels,the blood pressure level and fasting blood glucose level in SHR.Dietary puerarin administration decreased the body weight thus prevents obesity compared with that in the control group P0.01 or P0.05.More importantly,it can improved the endothelium-dependent relaxation of the aorta artery and lower the blood pressure level,compared to the high fat group,P0.01 or P0.05.Conclusion: Dietary puerarin had the cardiometabolic protection.It can improved the vasorelaxation and decreased the blood pressure,indicating that the puerarin had the perspective in treatment of obesity hypertension." @default.
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- W2359208523 date "2012-01-01" @default.
- W2359208523 modified "2023-09-25" @default.
- W2359208523 title "The Effects of Puerarin on Blood Pressure and the Vascular Function in Obesity-Hypertension Rats Model" @default.
- W2359208523 hasPublicationYear "2012" @default.
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