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- W2359217065 abstract "OBJECTIVE:To study the impact of amoxicillin on dysmenorrhea model mice treated with paeoniflorin.METHODS:The enrolled mice were randomized to different groups and all were given diethylstilbestrol i.g.for 12 consecutive days.From day 5 to day 12,the model control(MC)group,positive control(PC)group and 3 PA groups(different dosage of paeoniflorin plus amoxicillin)were given amoxicillin i.g.On day 12,3 P(paeoniflorin)groups and 3 PA groups were respectively given different dosage of paeoniflorin i.g.All groups were respectively given oxytocin i.p 1 hour after medication.The incubation period(TIP,seconds)between oxytocin i.p.and the first time of body twisting and the number of the body twisting(NBT)in 15 minutes of the mice were recorded.RESULTS:Compare to NC(negative control)and MC groups,the TIP was significantly prolonged and the NBT in 15min were significantly decreased in 3 P groups(P0.01～ 0.05),while the TIP and was prolonged and the NBT in 15min was decreased only in the large dosage PA group,and there were no significant differences in the other two PA groups(P0.05).CONCLUSION:The curative effect of paeoniflorin in treating dysmenorrheal model mouse was decreased by amoxicillin suggests that the 2 drugs were unsuitable to be used concomitantly." @default.
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- W2359217065 date "2007-01-01" @default.
- W2359217065 modified "2023-09-24" @default.
- W2359217065 title "Impact of Amoxicillin on Dysmenorrhea Model Mice Treated with Peoniflorin" @default.
- W2359217065 hasPublicationYear "2007" @default.
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