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- W2359239046 abstract "Objective To study the role of tumor necrosis factor-α(TNF-α)and plate-let deviced growth factor-BB(PDGF-BB)in the pathogenesis of adriamycin-induced nephropathy and the effects and moxonidine or monopril on them.Method Rats were received twice-intravenous injection of adriamycin and divided into nephropathy group(NEP)、moxonidine treatment group(for a dose of 1.5 mg/(kg·d)and monopril treatment group [10 mg/(kg·d)];10 healthy rats were as control group.At the end of the experiment,the proteinuria and nonepinephrine(NE)、angiotensin Ⅱ(AngⅡ)and TNF-α in blood were detected.Kidey damage were evaluated by quantitative histology.The protein expression of TNF-α and PDGF-BB were determined by immunohistochemical staining.Results Compared with control group,proteinuria and the levels of NE、AngⅡ and TNF-α in the blood were increased(P0.01),the expression of TNF-α and PDGF-BB in renal tissue were all significantly up-regulated(P 0.01)in adrianycin induced nephropathy rats.After the treatment of moxonidine and monopril,related parameters were all inhibited(P0.01).Conclusion Increased expression of TNF-α and PDGF-BB protein may play an important role in the progression of kidney disease,moxonidine and monopril can protect kidney by down-regulating the expression of TNF-αand PDGF-BB." @default.
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- W2359239046 date "2006-01-01" @default.
- W2359239046 modified "2023-09-26" @default.
- W2359239046 title "A comparison study between moxonidine and monopril effects on the expression of TNF-á in adriamy-cin induced nephropathy rats" @default.
- W2359239046 hasPublicationYear "2006" @default.
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