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- W2359246170 abstract "Objective To investigate changes in high mobility group 1 protein (HMG 1) gene expression in vital organs, and their potential role in mediating multiple organ damage after burns. ]MethodsWistar rats were subjected to a 35% total body surface area full thickness scald injury, and randomly divided into three groups: normal controls (7 rats), thermal injury (24), and recombinant bactericidal/permeability increasing protein (rBPI 21 ) treatment (12). Tissue samples from liver and lungs were collected to measure tissue endotoxin levels and HMG 1 mRNA expression. Blood samples were obtained for measurement of organ function parameters. Results HMG 1 gene expression in tissues was significantly increased at 24 hours postburn (liver: 0 487±0 189; lungs: 0 513±0 069, P 0 05,0 01), and remained markedly elevated up to 72 hours after thermal injury (liver: 0 687±0 142; lungs: 0 520±0 076, P 0 01). Treatment with rBPI 21 could significantly decrease tissue HMG 1 mRNA expression in vital organs (liver: 0 687±0 142; lungs: 0 520±0 076, P 0 01). Highly positive correlations were observed between hepatic HMG 1 mRNA and serum GPT, GOT levels, and also between pulmonary HMG 1 mRNA and MPO activities ( P 0 05 0 01). ConclusionsThermal injury per se can markedly enhance HMG 1 gene expression in various organs. Up regulation of HMG 1 expression may be involved in the pathogenesis of endotoxin mediated multiple organ damage secondary to major burns." @default.
- W2359246170 created "2016-06-24" @default.
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- W2359246170 date "2001-01-01" @default.
- W2359246170 modified "2023-09-28" @default.
- W2359246170 title "Changes of high mobility group 1 protein gene expression in rats after thermal injury" @default.
- W2359246170 hasPublicationYear "2001" @default.
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