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- W2359250367 abstract "Objective To investigate the relation between symptoms/pulmonary function and airway inflammation of asthmatic children through follow-up investigation on the pulmonary function and airway inflammatory,in order to provide basis for regular asthmatic therapy.Methods The pulmonary function and histamine challenge test of 32 cases of 7～14 years old asthmatic children under regular inhalation corticosteroid(ICS) therapy were carried out and the relation between the symptoms/pulmonary function and airway reactivity were evaluated.Results During the remission period after regular ICS therapy,the mean of one second force expiratory volume(FEV_1),25% and 50% of vital capacity of force expiratory flow(FEF_ 25 and FEF_ 50 ) predicted improved significantly when comparing with those prior to the therapy(P0.01);FEV_1 returned to normal at 3 months after the therapy,while ventilation function of the small airway did not return to normal until 1 year after the therapy;There were significant improvement of airway hyper-reactivity after the therapy(P0.01).However positive reaction to histamine challenge test persisted at 2-year after the therapy with a positive rate of 72% and all were slight airway hyper-reactivity.Conclusion Although the symptoms and pulmonary function approximat normal during asthmatic remission,most of the positive histamine challenge test results still persist,demonstrating that airway inflammation still exist.Regular pulmonary function test and histamine challenge test are effective indexes in guiding clinical therapy." @default.
- W2359250367 created "2016-06-24" @default.
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- W2359250367 date "2006-01-01" @default.
- W2359250367 modified "2023-09-28" @default.
- W2359250367 title "Significance of bronchial challenge test in the therapy of childhood asthma" @default.
- W2359250367 hasPublicationYear "2006" @default.
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