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- W2359251109 abstract "Objective To investigate the significance of the expression of three isoforms of Akt in the pathogenesis of psoriasis.Methods Immunohistochemistry method was used to detect the expression of Akt1,Akt2,Akt3 in lesions from 30 patients with psoriasis vulgaris and skin from 15 normal people.The expression levels of Akt1,Akt2,Akt3 were analyzed by measurement of the average optical density of immunostaining.Results The expression of both Akt1(0.2170±0.0144) and Akt2(0.2157±0.0150) in psoriatic lesions had no obvious differences compared with that of normal skin(P0.05,respectively).However,the expression of Akt3(0.2990±0.0165) in psoriatic lesions was significantly higher than that in normal skin(P0.01).Conclusion The increased expression of Akt3 might be correlated to the elevation of phosphorylated Akt and Akt activity in psoriatic lesions." @default.
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- W2359251109 date "2011-01-01" @default.
- W2359251109 modified "2023-09-28" @default.
- W2359251109 title "The Expression of Akt1,Akt2,Akt3 in the Lesions of Psoriasis Vulgaris" @default.
- W2359251109 hasPublicationYear "2011" @default.
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