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- W2359257569 abstract "Objective:To determine the O/W partition coefficients(logP)of guanine antiviral agents.And the ex- perimental results were compared with the theoretical values.Method:The HPLC method was applied with the mo- bile phase consisting of acetonitrile-aqueous solution(500 mL water+0.5 mL triethylamine+0.5 mL acetic acid,pH=4-5)(5:95),the flow rate was 1.0 mL·min~(-1).The correlation between the logP and structure of the medicine was detailed with the fragmental constant.Results:The errors of measurement are within the logP error range(10%).Conclusion:The results determined by HPLC conform to the popular standard." @default.
- W2359257569 created "2016-06-24" @default.
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- W2359257569 date "2005-01-01" @default.
- W2359257569 modified "2023-09-24" @default.
- W2359257569 title "HPLC Studies on the Correlation Between the O/W Partition Coefficients and the Structure of Guanine Antiviral Agent" @default.
- W2359257569 hasPublicationYear "2005" @default.
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