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- W2359261442 abstract "Objective To determine the maximum tolerated dose(MTD) and dose-limiting toxicity(DLT) of hypofractionated conformal radiotherapy(HFRT)with concurrent weekly medium-dose gemcitabine(GEM) in patients with unresectable pancreatic cancer.Methods Ten patients with previously untreated,locally advanced,or asymptomatic-metastatic pancreatic adenocarcinoma were enrolled in this study.GEM at a dose of 600 mg/m2 was given intravenously over 30 minutes starting 2 hours before radiotherapy weekly for 7 weeks.The initial radiation dose was 48 Gy in 12 fractions(3 fractions/week) with three patients(level 1).Radiation dose was escalated by 4Gy increments in successive cohorts of 3 to 6 additional patients until DLT was observed.Toxicities were graded using the Radiation Therapy Oncology Group and National Cancer Institute Common Toxicity Criteria,version 3.0.Results In general,therapy was well tolerated in patients treated at the first two dose levels of 48Gy/12 fractions and 52Gy/13 fractions.The DLT of HFRT with concurrent weekly medium-dose GEM were neutropenia(2 patients),thrombocytopenia(2 patients),at the dose level of 56Gy/14 fractions.Of the 10 patients eligible for a median follow-up of 10 months,1 complete response,3 partial response,and 5 with stable disease,and the median overall survival time was 12 months.Conclusion The final radiation dose investigated(52Gy/13 fractions,3 fractions/week) is recommended for further study considering the occurrence toxicity." @default.
- W2359261442 created "2016-06-24" @default.
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- W2359261442 date "2011-01-01" @default.
- W2359261442 modified "2023-09-23" @default.
- W2359261442 title "A phase I study of hypofractionated conformal radiation dose escalation with concurrent weekly medium-dose gemcitabine in patients with unresectable pancreatic cancer" @default.
- W2359261442 hasPublicationYear "2011" @default.
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