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- W2359266310 abstract "Objective:To observe the renal changes of aristolochic acid-induced nephrotoxicity by long-term using different dose of Caulis Aristolochiae Manshuriensis Extract (CAME) in rats,and investigate the relationship between the changes and blood aristolochic acid-A concentration. Method:Male SD rats were randomized into 5 groups:normal diet control group,low-salt diet control group,Low-,Mid-,and High-dose groups. Renal function and morphological changes in renal tissue were observed at 4 and 6 weeks after treatment with CAME,respectively. The aristolochic acid-A concentration in blood was determined by LC-MS-MS method. Result:Compared with low-salt diet control group,the urine volumes in 3 groups were increased at the 2nd weeks. At the 4th weeks,the urine volumes were decreased; other renal changes in low-and mid-dose groups were not obvious; the levels of urine protein and BUN were remarkably increased in high-dose group. At the 6th weeks,the urine volume was decreased in high-dose group and the levels of urine protein,Crea and BUN were significantly increased. Morphologic changes consisted of vacuolization of renal tubular cells,hyalinization of small arterioles and the light renal interstitial fibrosis. All the injury changes in High-dose group were more severe than those in low-and mid-dose groups. The parameters in two control groups had no statistical significance. The plasma aristolochic acid-A concentration was very low. Conclusion:Long-term use of CAME in rats results in renal function and morphological changes,which correlated with time and dosage of used CAME and might be independence to plasma aristolochic acid-A concentration." @default.
- W2359266310 created "2016-06-24" @default.
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- W2359266310 date "2010-01-01" @default.
- W2359266310 modified "2023-09-25" @default.
- W2359266310 title "Changes of Caulis Aristolochiae Manshuriensis Extract-induced Chronic Nephrotoxicity and Relationship between Changes and Plasma Concentration" @default.
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