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- W2359275973 abstract "Objective To investigate the curative effect of human umbilical cord mesenchymal stem cells(hUCMSCs)on acute liver failure as well as optimization of transplantation approach.Methods Forty-eight SD rats were randomly divided into four groups,i.e.blank control group,model control group and test groups A and B,12 for each.The rats in model control group and test groups A and B were injected i.p.with 50% carbon tetrachloride solution to establish the model of acute liver failure,while those in blank control group were untreated.Twenty-four hours after the establishment of model,the rats in model control group were injected i.v.with 1 ml of physiological saline,while those in blank control group and test groups A with 1 ml of suspension of hUCMSCs.However,0.3 ml of suspension of hUCMSCs were injected into livers of rats in test group B.Serum samples were collected at various time points after treatment and determined for albumin(ALB),total bilirubin(TBil)and alanin aminotransferase(ALT)contents by full-automatic biochemical analyzer.The human CK8,CK18 and AFP gene levels in liver tissues of rats in various groups were determined by real-time PCR 1 and 2 weeks after treatment.The expression of human CK18 protein in liver tissues of rats in various groups were determined by immunohistochemical assay with SP staining 3 d,1 week and 2 weeks after treatment.Results The ALB,TBil and ALT contents in test groups 24 and 48 h after treatment showed significant differences with those in model control group(each P 0.05).The CK8,CK18 and AFP gene levels 1 and 2 weeks after treatment were significantly higher in test groups A and B than in model control group(each P 0.01),and increased gradually with the increasing time.The expression of CK18 protein was observed in liver tissue of rats 3 d after treatment,while hUCMSCs were differentiated and migrated from the portal area to the central vein region.No significant differences were observed in the liver function indexes or differen tiation levels of hUCMSCs in test groups A and B(P 0.05).Conclusion The hUCMSCs promoted the repair of liver of rats with acute liver failure,and differentiated to liver-like cells with function of liver cells,of which the curative effect by transplantion through intravenous injection was similar to that through injection into liver.However,the transplantation by intravenous injection was easier to be applied and popularized." @default.
- W2359275973 created "2016-06-24" @default.
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- W2359275973 date "2013-01-01" @default.
- W2359275973 modified "2023-09-23" @default.
- W2359275973 title "Curative effect of mesenchymal stem cells on acute liver failure and optimization of transplantation approach" @default.
- W2359275973 hasPublicationYear "2013" @default.
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