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- W2359282313 abstract "Objective To probe the effect of Intermittent exercise on ADM,Receptor activity modifying protein(RAMP2) and Calcitonin receptor like receptor(CRLR) in myocardial cytoprotection of rat,we study the function and mechinsm of Adrenomedullin(ADM) in myocardial cytoprotection inducd by IE in heart of rat.Method Sprague–Dawley rats(n=30) were randomly into two groups: control group(C),intermittent exercise group(IE).The rats of IE group performed 3 weeks intermittent treadmill exercise in order to establish animal model.The contents of ADM in serum and myocardium were investigated using euzymelinked immunosorbent assay and RAMP2 and CRLR in myocardium were investigated using Western blot.Result As compared with the control,the content of serum ADM were not obvious change but contents of ADM in myocardium were obvious increased and RAMP2 and CRLR also were obviously increased.Conclusion The results suggested that secretion and releasing of ADM in myocardium by intermittent exercise and its specificity receptor RAMP2 and CRLR also were obviously increased follow in myocardial.That increase of Adrenomedullin and specificity receptor leads to up-regulation and exercise adaptit of heart and plays an important role in keeping haemodynamics stabilization and myocardial cytoprotection in exercise." @default.
- W2359282313 created "2016-06-24" @default.
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- W2359282313 date "2011-01-01" @default.
- W2359282313 modified "2023-09-25" @default.
- W2359282313 title "Effect of Intermittent Exercise on RAMP_2 and CRLR of Adrenomedullin Specificity Receptor" @default.
- W2359282313 hasPublicationYear "2011" @default.
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