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- W2359283191 abstract "OBJECTIVE To observe the effect of Kudiezi(KDZ,Ixeris sonchifolia) against cerebral infarction in rats and its possible mechanisms.METHODS Model of cerebral ischemia repefusion in rats with cerebral arterial occlusion was established by thread ligation in fifty rats.Fifty rats were randomly divided into five groups:sham operation group,cerebral ischemia mode group,KDZ high dos group,KDZ middle dos group and KDZ low dos group with 10 rats in each group.Drug were given to KDZ groups four times totally,respectively 20 minutes ahead of brain ischemia and 12 hours,24 hours,36 hours after brain ischemia,intraperitoneal injection.Normal saline of the same dos were given to the sham operation group and cerebral ischemia mode group,Affuse 46 h after 2 hours of brain ischemia,then calculated grades of nerve function disfigurement,compute brain index and observed the activity of Na+-K+-ATPase and Ca2+-ATPase.RESULTS Compared with cerebral ischemia model group,grades of nerve function disfigurement and brain indexs in KDZ high dos group,KDZ middle dos group and KDZ low dos group were declined according to the dos of KDZ,while the activity of Na+-K+-ATPase and Ca2+-ATPase was raised according to the dos.CONCLUSION Kudiezi afforded protection against repefusion injury of cerebral ischemia possibly because of the raise of the activity of Na+K+-ATPase and Ca2+-ATPase." @default.
- W2359283191 created "2016-06-24" @default.
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- W2359283191 date "2009-01-01" @default.
- W2359283191 modified "2023-09-26" @default.
- W2359283191 title "The protective effect of Kudiezi injection against cerebral ischemia /repefusion injury in rats" @default.
- W2359283191 hasPublicationYear "2009" @default.
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