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- W2359285554 abstract "Objective: Many studies showed that ardiomyocytes injury had related to ion channel, to study the effects of melatonin on heart tissue in C57BL/6 mice caused by low selenium diet and discuss the possible mechanism. Methods: The mice were divided into four group, with three treatment groups fed with selenium-deficient diet(0.0045 μg/g) for control group, 30 day low-selenium, 90 day low-selenium, 180 day low-selenium. Then selenium and heart tissues were examined in mice. Western Blotting was employed to identify the down-stream protein of potassium channel protein expression level. Results: Compared with the control group, the selenium levels of the 30 days, 90 days and 180 days selenium deficiency mice were reduce(P0.01) and there was cardiomyocytes injury. And the expression of potassium channel protein in 30 days, 90 days and 180 days selenium deficiency mice was also down-regulated(P0.05). Conclusion: We established a selenium-deficient mice model successful. Low selenium can caused cardiomyocytes injury and these changes might be caused by the level of potassium channel protein." @default.
- W2359285554 created "2016-06-24" @default.
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- W2359285554 date "2014-01-01" @default.
- W2359285554 modified "2023-09-26" @default.
- W2359285554 title "Study of Relationship between Cardiomyocytes Injury Induced by Selenium-deficiency and Potassium Channel Protein" @default.
- W2359285554 hasPublicationYear "2014" @default.
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