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- W2359291785 abstract "OBJECTIVE To improve the stability of isotretinoin through solid lipid nanoparticles(SLN)as carrier for it.METHODS Prepare isotretinoin SLN by nanoemulsion method.RESULTS The shape of SLN was spherical or similar,the mean particle size was 53.23nm,entrapment efficiency was over 97%.Both drug content and entrapment efficiency of SLN had no significant change after storage at 25℃ and 40℃ in a light-resistant container for 6 months.CONCLUSION It’s more easy for prepare isotretindin SLN by nanoemulsion method,and the product have good stability." @default.
- W2359291785 created "2016-06-24" @default.
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- W2359291785 date "2010-01-01" @default.
- W2359291785 modified "2023-09-23" @default.
- W2359291785 title "Study on the preparation and stability of isotretinoin solid lipid nanoparticles" @default.
- W2359291785 hasPublicationYear "2010" @default.
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