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- W2359295980 abstract "Objective To investigate the effects of sodium iodide and IL-1β on the expression of TNF-related apoptosis-inducing ligand(TRAIL) and apoptosis of human thyrocytes primary cultured in vitro.Methods Human thyroid epithelial cells were primary cultured from normal thyroid tissues,or tissues with Graves Disease(GD) and Hashimoto thyroiditis(HT).They were cultured in the absence or presence of sodium iodide or IL-1β with different concentrations,which were separated into normal control,HT and GD groups.Expressions and distributions of TRAIL in thyrocytes of HT,GD and normal groups were investigated with immunocytochemistry method and flow cytometry was used to determine the expression of TRAIL and apoptosis.Results(1) The expression level of TRAIL in GD and HT thyrocytes was increased significantly compared to control group(P0.05).(2) The positive rate of TRAIL in the normal and GD group was significantly higher with 10 mg/L sodium iodide than that with 1 mg/L sodium iodide(P0.05).In the HT group,the expression of TRAIL with 100 mg/L sodium iodide was significantly higher than that with 1 mg/L sodium iodide(P0.01).(3)The rate of apoptosis in the human thyrocytes from HT group was significantly higher than that from the normal or GD group(P0.01).(4) A high concentration of cytokine IL-1β could induce TRAIL expression in all three groups of thyrocytes.Conclusions The expression of TRAIL in the human thyrocytes from thyroid tissues with GD or HT is higher than those from normal tissues.Under the condition of excess iodine or IL-1β,the expression of TRAIL is increased,which may induced apoptosis of thyroid cells,and further lead to functional and pathologic changes in thyroid grand." @default.
- W2359295980 created "2016-06-24" @default.
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- W2359295980 date "2011-01-01" @default.
- W2359295980 modified "2023-09-28" @default.
- W2359295980 title "Effects of Sodium Iodide and IL-1β on the Expression of TRAIL in Human Thyrocytes" @default.
- W2359295980 hasPublicationYear "2011" @default.
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