FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359302896> ?p ?o ?g. }

• W2359302896 abstract "Objective: To explore the mechanism of total flavonoids extracted from Bai Hua She She Cao(Hedyotis diffusa Willd) inhibiting tumor and the influence of benzo(a)pyrene on the immunity of the body by detecting the levels of IL-2 and IL-6. Methods: Sixty mice were randomly divided to 20 ones in the control group and 40 in the experiment group of benzo(a)pyrene, 40 mice in the experiment group of benzo(a)pyrene were randomized into two groups: 10 mg/kg benzo(a)pyrene group and 20 mg/kg benzo(a)pyrene group, with 20 mice in each group, they were kept in the cage with half male and half female, and they accepted peritoneal injection of benzo(a)pyrene in the concentrations of 10mg/kg and 20mg/kg after dissolving benzo(a)pyrene in dimethyl sulphoxide(DMSO), once per day, for ten consecutive times, in the control group, each rat received peritoneal injection of DMSO, 100 m L, The experiment groups of benzo(a)pyrene with the concentrations of 10mg/kg and 20mg/kg were divided into high dosage group and low dosage groups of total flavonoids extracted from Bai Hua She She Cao in two months(total flavonoids extracted from Bai Hua She She Cao by ethanol refluxing method), ten mice each group, and they were perfused with Bai Hua She She Cao liquid extract in the concentrations of 20 g/kg and 10 g/kg, once per day,the tissues were obtained after two consecutive weeks. ELISA method was to detect the levels of IL-2 and IL-6 in the serum; the organs including liver, spleen, kidney, pancreas, stomach, lung and others were taken out and fixed in formaldehyde solution, embedded, sectioned, stained and observed under microscope. Results: The concentrations of IL-2 in the control group, 10mg/kg benzo(a)pyrene group and 20mg/kg benzo(a)pyrene group were respectively(360.00±15.92) ng/L,(92.59±6.12) ng/L and(83.84±5.89) ng/L, the experiment groups were lower than the control group significantly; high dosage group of total flavonoids extracted from Bai Hua She She Cao was lower than that of low dosage group. The concentrations of IL-6 in the control group, 10mg/kg benzo(a)pyrene group and 20mg/kg benzo(a)pyrene group were respectively(32.65±5.32) pg/m L,(21.78±4.62) pg/m L and(24.54±9.89) pg/m L, the differences was insignificant when they were compared with the control group; the difference was insignificant between high dosage group and low dosage group of total flavonoids extracted from Bai Hua She She Cao. Benzo(a)pyrene could harm liver, stomach and kidney evidently, compared with the control group, the difference was significant in precancerous lesion rate; 20mg/kg benzo(a)pyrene group was higher than 10mg/kg benzo(a)pyrene group clearly in stomach harm, it showed dose-effect relationship significantly; there was no obvious harm to lung and pancreas in the experiment group. Conclusion: Different experiment groups are lower than the control group in the concentrations of IL-2, which indicates that benzo(a)pyrene could inhibit cellular immunity of the body notably; benzo(a)pyrene could harm liver, stomach and kidney obviously; the incidence of gastric cancer indicates dose-effect relationship clearly. High dosage group of total flavonoids extracted from Bai Hua She She Cao is higher than low dosage group in the concentrations of IL-2, while the comparison had no difference in the concentrations of IL-6, it suggests that total flavonoids extracted from Bai Hua She She Cao could regulate cellular immunity to a certain extent, the mechanism might be related to regulating the functions of T cells and fighting against bone marrow arrest of chemotherapeutics." @default.
• W2359302896 created "2016-06-24" @default.
• W2359302896 creator A5048534671 @default.
• W2359302896 date "2015-01-01" @default.
• W2359302896 modified "2023-09-27" @default.
• W2359302896 title "Impact of Total Flavonoids Extracted from BaiHua SheSheCao on the Levels of IL-2 and IL-6 of Mice with Solid Tum or Induced by Benzo(a)pyrene" @default.
• W2359302896 hasPublicationYear "2015" @default.
• W2359302896 type Work @default.
• W2359302896 sameAs 2359302896 @default.
• W2359302896 citedByCount "0" @default.
• W2359302896 crossrefType "journal-article" @default.
• W2359302896 hasAuthorship W2359302896A5048534671 @default.
• W2359302896 hasConcept C140793950 @default.
• W2359302896 hasConcept C178790620 @default.
• W2359302896 hasConcept C185592680 @default.
• W2359302896 hasConcept C2777538855 @default.
• W2359302896 hasConcept C2778951431 @default.
• W2359302896 hasConcept C55493867 @default.
• W2359302896 hasConcept C556039675 @default.
• W2359302896 hasConcept C71924100 @default.
• W2359302896 hasConcept C86803240 @default.
• W2359302896 hasConcept C98274493 @default.
• W2359302896 hasConceptScore W2359302896C140793950 @default.
• W2359302896 hasConceptScore W2359302896C178790620 @default.
• W2359302896 hasConceptScore W2359302896C185592680 @default.
• W2359302896 hasConceptScore W2359302896C2777538855 @default.
• W2359302896 hasConceptScore W2359302896C2778951431 @default.
• W2359302896 hasConceptScore W2359302896C55493867 @default.
• W2359302896 hasConceptScore W2359302896C556039675 @default.
• W2359302896 hasConceptScore W2359302896C71924100 @default.
• W2359302896 hasConceptScore W2359302896C86803240 @default.
• W2359302896 hasConceptScore W2359302896C98274493 @default.
• W2359302896 hasLocation W23593028961 @default.
• W2359302896 hasOpenAccess W2359302896 @default.
• W2359302896 hasPrimaryLocation W23593028961 @default.
• W2359302896 hasRelatedWork W2005962706 @default.
• W2359302896 hasRelatedWork W2073595121 @default.
• W2359302896 hasRelatedWork W2136460167 @default.
• W2359302896 hasRelatedWork W2158714819 @default.
• W2359302896 hasRelatedWork W2347457636 @default.
• W2359302896 hasRelatedWork W2347633888 @default.
• W2359302896 hasRelatedWork W2354718604 @default.
• W2359302896 hasRelatedWork W2355556594 @default.
• W2359302896 hasRelatedWork W2366887873 @default.
• W2359302896 hasRelatedWork W2368556032 @default.
• W2359302896 hasRelatedWork W2369685727 @default.
• W2359302896 hasRelatedWork W2370556798 @default.
• W2359302896 hasRelatedWork W2372440350 @default.
• W2359302896 hasRelatedWork W2376057913 @default.
• W2359302896 hasRelatedWork W2391631918 @default.
• W2359302896 hasRelatedWork W2602985914 @default.
• W2359302896 hasRelatedWork W3025348430 @default.
• W2359302896 hasRelatedWork W3031184027 @default.
• W2359302896 hasRelatedWork W3032494009 @default.
• W2359302896 hasRelatedWork W3088264993 @default.
• W2359302896 isParatext "false" @default.
• W2359302896 isRetracted "false" @default.
• W2359302896 magId "2359302896" @default.
• W2359302896 workType "article" @default.