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• W2359306067 abstract "Objective To explore the correlation of serum level of human mammaglobin(h MAM) with early diagnosis and micro-metastasis of breast cancer and to study the clinical significance of h MAM. Methods The serum levels of h MAM in 64 patients with breast cancer,32 patients with other cancers(8 patients with prostate cancer,8 patients with gastric cancer,8 patients with ovarian cancer and 8 patients with colorectal cancer),34 patients with benign breast disease and 36 healthy females(control group) were determined by enzyme linked immunosorbent assay(ELISA) and their results were analyzed. These 64 patients with breast cancer were classified by TNM staging,they were grouping according to the existence of expression of estrogen receptor(ER),metastasis in axillary lymph nodes and menopause. The cut-off value of serum level of h MAM in patients with breast cancer was determined by receiver operating characteristic(ROC) curve. Results The area under ROC curve of serum level of h MAM was 0. 855,and the reliability of diagnosis in breast cancer was 85. 5% [95% confidence interval(CI) : 72. 6% ~ 92.4%]. When the cut-off value of h MAM was 8. 54 ng/ml,the respective specificity and sensitivity were 83. 2% and 75. 9% respectively. Serum level of h MAM and positive rate in breast cancer group was significantly higher than that of benign breast disease group,other cancer group and control group(P 0. 05). The difference among benign breast disease group,other cancer group and control group was not statistically significant(P 0. 05). The positive rates of serum level of h MAM in patients with III and IV stages breast cancer(62. 50% and 75. 00%) were significantly higher than those of patients in I and II stages(31. 25% and 37. 50%,P 0. 05),but there was no difference in levels of h MAM(P 0. 05). The positive rate of serum h MAM in patients with breast cancer associated with metastasis in axillary lymph nodes(90. 91%) was significantly higher than those without metastasis(25. 00%,P 0. 05),but the difference in serum level of h MAM was not significant(P 0. 05).Regardless of whether existed ER expression and menopause,serum level of h MAM and positive rate in patients with breast cancer had no difference(P 0. 05). with those without metastasis(25. 00%,P 0. 05),but the difference in serum level of h MAM was not significant(P 0.05). Conclusion There are correlation between clinical TNM staging of patients with breast cancer and the degree of metastatsis in axillary lymph nodes. In screening of breast tumor in high risk female patients,the examination of serum level of h MAM is helpful in early detection of patients with breast cancer. It is also important in early detection of micro-metastasis and early treatment." @default.
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• W2359306067 date "2015-01-01" @default.
• W2359306067 modified "2023-09-23" @default.
• W2359306067 title "Study on clinical significance of correlation of serum level of human mammaglobin with early diagnosis of breast cancer and micrometastasis of cancer" @default.
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