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- W2359306587 abstract "Objective: To investigate the effects of matrine injection(MI) on expressions of mRNAs and proteins of vascular endothelial growth factor(VEGF)and CXC chemokine receptor 4(CXCR4) in gastric carcinoma SGC-7901 cells.Methods: Methyl thiazolyl tetrazolium assay(MTT) was used to examine the effects of MI on proliferation of SGC-7901 cells;Reverse transcription-polymerase chain reaction(RT-PCR),immunofluorescence and enzyme-linked immunosorbent assay(ELISA) were employed to measure the expressions of VEGF and CXCR4 mRNAs and proteins of the cells respectively.Results: MI could inhibit the proliferation of SGC-7901 cells,with obvious dose-dependent and time-dependent effects;With the increasing concentration of MI for 24h,the expressions of VEGF and CXCR4 mRNAs and proteins of SGC-7901 cells reduced gradually,which had statistical significance compared with the control group(P0.05).Conclusion: MI can inhibit the expressions of gastric carcinoma vascular endothelial growth factor markedly,which may be one of its mechanisms in anti-angiogenic ability." @default.
- W2359306587 created "2016-06-24" @default.
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- W2359306587 date "2010-01-01" @default.
- W2359306587 modified "2023-09-23" @default.
- W2359306587 title "Effects of matrine injection on expressions of mRNAs and proteins of VEGF and CXCR4 in gastric carcinoma SGC-7901 cells" @default.
- W2359306587 hasPublicationYear "2010" @default.
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