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- W2359306835 abstract "Objective To investigate the restoration of the subcellular distribution of daunorubicin in the P glycoprotein mediated multidrug resistant cell line K562/ADR by quercetin. Methods The effect of quercetin on the subcelluar distribution of DNR in K562/ADR was under taken by confocal scanning laser microscopy (CSLM). Results Compared with the drug sensitive cell K562/S in which DNR fluorescence appeared diffusely in the nucleus and cytoplasm, DNR in K562/ADR cells was distributed at the perinuclear region and peripheral cytoplasm. Quercetin could markedly restore the diffuse cytoplasmic and nuclear fluorescence distribution in the resistant cell line. Conclusion Quercetin can restore the altered subcellular disposition of DNR in resistant cell line, which is involved in the mechanism of multidrug resistance." @default.
- W2359306835 created "2016-06-24" @default.
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- W2359306835 date "2003-01-01" @default.
- W2359306835 modified "2023-09-23" @default.
- W2359306835 title "Study of quercetin on the restoration of the subcellular distribution of daunorubicin in the P-glycoprotein-mediated multidrug-resistant cell line K562/ADR" @default.
- W2359306835 hasPublicationYear "2003" @default.
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