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- W2359307558 abstract "Objective:To develop an LC-MS/MS method based on liquid chromatography with tandem mass spectrometry detection for the determination of emodin of Rhizoma Polygoni Cuspidati in plasma and brain of rat.Method:The column was Eclipse Plus-C18 (50 mm×2.1 mm,1.8 μm),mobile phase was 5 mmol·L-1 NH4Ac solution-acetonitrile (1∶1,v/v) at a flow rate of 0.2 mL·min-1.The analyte was detected using negative ionization by multiple reaction monitoring mode.The mass transition paires of m/z 269.2 and 181.9 was applied to detect emodin.Results:The assay exhibited a good linearity in the concentration range from 0.03-6 μg·mL-1 with a correlation coefficient of 0.9989 from rat plasma.The method recoveries of emodin were from 95.9% to 117.2% and the extraction recoveries of emodin were from 87.8% to 120.3% at three concentration levels from rat plasma samples.A good linearity in the concentration range from 5.0-1000 ng·g-1 with a correlation coefficient of 0.9999 from rat brain.The method recoveries of emodin were from 99.1% to 103.1% and the extraction recoveries of emodin were from 94.1% to 97.2% at three concentration levels from rat brain samples.Conclusion:This method is accurate,precise,sensitive and specific,and can be applied to the determination of emodin in biological specimen." @default.
- W2359307558 created "2016-06-24" @default.
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- W2359307558 date "2009-01-01" @default.
- W2359307558 modified "2023-09-24" @default.
- W2359307558 title "LC-MS/MS determination of plasma and brain concentration of emodin in rats" @default.
- W2359307558 hasPublicationYear "2009" @default.
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