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- W2359308910 abstract "Objective To observe the changes in plasma C type natriuretic peptide(CNP) and C reaction protein(CRP) levels and the preventive effect of exogenous CNP on vascular stenosis in a diabetic rabbit model after femoral artery injury.Methods After setting up an animal model of diabetes,the rabbits were divided into the control group(n=8),artery injury group(n=8) and CNP treatment group(n=8).Enzyme-linked immunosorbent assay was used in determination of plasma CRP and CNP concentration.Histological changes in the femoral artery wall were evaluated by HE staining to determine the degree of stenosis.Results The post operative CRP concentration of the artery injury group compared with CNP treatment group was 13.81±4.30 μg/mL vs 8.43±0.61 μg/mL(P0.01) after 1 day,9.38±2.99 μg/mL vs 6.79±4.39 μg/mL(P0.01) after 7 days and 6.88±0.92 μg/mL vs 5.79±0.64 μg/mL(P0.01) after 14 days,respectively.The area of the medial layer and the intimal layer of fermoral arteries compared between the artery injury group and the CNP treatment group were(0.14±0.05 mm2 vs 0.28±0.18 mm2,P0.01;0.07±0.03 mm2 vs 0.14±0.09 mm2,P0.01),respectively.Conclusion CNP can influence the process of femoral artery recovery after balloon injury in rabbit diabetic models and may suppress the femoral artery stenosis." @default.
- W2359308910 created "2016-06-24" @default.
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- W2359308910 date "2009-01-01" @default.
- W2359308910 modified "2023-09-26" @default.
- W2359308910 title "C type natriuretic peptide in femoral atery stenosis in diabetic rabbit models" @default.
- W2359308910 hasPublicationYear "2009" @default.
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