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- W2359326712 abstract "AIM:To evaluate the therapeutic effect and to observe the changes of levels of serum cytokine soluble interleukin-2 receptors(sIL-2R)and interleukin-8(IL-8)and the absolute number of eosinophil in blood(EOS)of roxithromycin combined with inhaled budesonide(BUD)dry powder inhalation(pulmicort turbuhaler)on asthma,comparing with the inhaled pulmicort turbuhaler group.METHODS:45 asthmatic subjects were randomly treated with either roxithromycin combined with pulmicort turbuhaler(treatment group)or pulmicort turbuhaler(control group).The treatment course was 4 weeks.Before the treatment and after 4 weeks of the treatment,the levels of sIL-2R,IL-8,EOS and lung function were detected,as well as the scoring of clinical symptoms.RESULTS:There were 40 subjects who fulfiled their trials.Both clinical symptoms scores and lung function,FEV1,FEV1/pred%,PEF and PEF/pred% were significantly improved in both groups after treatment.The levels of sIL-2R,IL-8 and EOS were significantly decreased in both groups after treatment.Moreover,the indexes in treatment group were significantly improved than those in control group.The side effects in both groups were similar.CONCLUSION:Roxithromycin has anti-inflammatory and immunoregulatory effects on treating asthma.Roxithromycin associated with pulmicort turbuhaler can enhance curative effect on asthma." @default.
- W2359326712 created "2016-06-24" @default.
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- W2359326712 date "2008-01-01" @default.
- W2359326712 modified "2023-09-23" @default.
- W2359326712 title "Clinical study on efficacy of roxithromycin combined with inhaled budesonide dry powder inhalation on asthma" @default.
- W2359326712 hasPublicationYear "2008" @default.
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