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- W2359331880 abstract "Objective To analyze the clinical-pathological and biological features of breast cancer patients with false-negative mammograms so as to study its prognosis and provide an evidence for the treatment. Methods One hundred eighty-nine female patients with breast cancer,which was confirmed pathologically in No.4 Hospital of Hebei Medical University and Cangzhou Central Hospital from January to April in 2006,were divided into two groups:a positive group and a false negative group according to their mammogram results. The immunohistochemistry method (Streptavidin-Peroxidase (S-P) method) was used to determine ER,PR,C-erbB-2 and VEGF of the patients. And the related analyses were made in combination with the clinical indexes. Results In the false-negative group,the menopause patients only accounted for 28.57% (10/35),which was lower than that of the non-menopause patients(χ 2 = 7.748 ,P= 0.008); the patients suffering from medullary carcinama and mucinous adenocarcinima accounted for 27.27% (10/35),which was higher than that 4.11% (6/148) of the positive group,with statistical difference (P=0.000). According to TNM stages,the stage I rate of the false negative group was lower than that of the positive group (14.30%vs82.56%,P=0.000). For histological grade,the rate of grade III was 23.08% (8/35) in the false-negative group,which was obviously higher compared with 3.26% (χ 2 =4.952,P=0.024) in the positive group. The ER positive rate was lower in the false-negative group than in the positive group (40%vs67.57%,P=0.003).But there were no differences in age,tumor size,axillary lymphatic metastasis and PR between the twogroups (P 0.05). The biological feature analysis of the tumor showed the strong positive expression rate of C-erbB-2 in the false negative group was lower than that of the positive group (25.71% vs 51.35%,P=0.008). But there was no difference in the VEGF expression rate between the two groups (P0.05). Conclusion Breast cancer with false-negative mammograms has higher incidence in non-menopause patients. Patients with medullary carcinoma and mucinous adenocarcinoma account for a certain proportion,with low incidence of early breast cancer. It is suggested that breast cancer with false-negative mammograms results from the dense breasts and pathological types showing frequently benign clinical features in non-menopause patients. However,poor differentiation of tissues,lower positive expression rate of ER and lower strong positive rate of C-erbB-2 show that the patients are suited to auxiliary chemotherapy after operation." @default.
- W2359331880 created "2016-06-24" @default.
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- W2359331880 date "2007-01-01" @default.
- W2359331880 modified "2023-09-24" @default.
- W2359331880 title "Analysis of clinical-pathological and biological features of breast cancer with false-negative mammograms" @default.
- W2359331880 hasPublicationYear "2007" @default.
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