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- W2359343478 abstract "Objective To explore the expressions and significance of integrin β4 and S100A4 in different molecular subtypes of invasive ductal carcinoma of breast. Methods A total of217 patients with invasive ductal carcinoma of breast from February 2008 to January 2013 were selected. The expressions of integrin β4 and S100A4 in each cancer tissue were detected by immunohistochemical method,and its relationship with molecular subtypes was analyzed. Results There were significant differences in tumor primary lesions,lymphatic metastases and histological grading of different molecular subtypes of invasive ductal carcinoma of breast( P 0. 05). The positive rates of integrinβ4 in Luminal A,Luminal B( HER2-),Luminal B( HER2 +),Erb-B2 over-expression and basallike types were 17. 39%, 5. 88%, 6. 06%, 65. 96% and 67. 86% respectively,whilepositive rates of S 1 0 0 A 4 in these types were 2 6. 0 9 %,2 9. 4 1 %,2 7. 2 7 %,7 2. 3 4 % and71. 43%. There were significant differences of positive rates of integrin β4 protein expression in each type,whereas there were significant differences of positive rates of S100A4 protein expression in Luminal A,Erb-B2 over-expression and basal-like types( P 0. 05 or P 0. 01). Conclusion Both Integrin β4 and S100A4 are highly expressed in Erb-B2 over-expression and basal-like types of invasive ductal carcinoma of breast,which may be correlated with tumor cell infiltration and metastasis." @default.
- W2359343478 created "2016-06-24" @default.
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- W2359343478 date "2015-01-01" @default.
- W2359343478 modified "2023-09-23" @default.
- W2359343478 title "Expressions and significance of integrin β4 and S100A4 in different molecular subtypes of invasive ductal carcinoma of breast" @default.
- W2359343478 hasPublicationYear "2015" @default.
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