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- W2359353667 abstract "Effects of cardiovascular functions (blood pressure, resting heart rate and PR interval prolongation) and pharmacodynamics of racemic verapamil (VPM) administrated by oral and intravenous infusion were evaluated in eight healthy Chinese male volunteers. Plasma concentrations of the enantiomers of verapamil(VPM) were determined by capillary zone electrophoresis using trimethyl--cyclodextrin as chiral selector. Pharmacodynamic parameters of total VPM and S-(-)-VPM concentrations to percentage of PR interval prolongations were predicted using pharmacokinetic pharmacodynamic combined model at nonsteady-state after single dosages. The pharmacodynamic parameters, Emax(%), CE50(gL-1), Keo and of VPM after oral dosage were 43.721.1, 69.430.3,3.644.7 and 2.852.01 respectively;The pharmacodynamic parameters, Emax(%), CE50(gL-1), Keo and of S-(-)-VPM after oral administration were 47.726.9,14.38.5,5.235.5 and 3.241.8 respectivly. The pharmacodynamic parameters, Emax(%), CE50(gL-1), Keo and of VPM after Acknowledgements The author would like to acknowledge Dr. Longstreth (Searle Co., Skokie, IL,USA ) for kindly providing the standards of R-(+)-VPM(HCL,S-(-)-VPM(HCL,()NVPMHCL, R-(+)-NVPMHCL and S-(-)-NVPMHCL. intravenous infusion were 35.213.3,29.712.9,6.363.2 and 2.281.6 respectively; The pharmacodynamic parameters , Emax(%), CE50(gL-1), Keo and of S-(-)-VPM after intravenous infusion were 35.717.2,13.48.41,7.133.422.521.52 respectively. Thus, It is of more significance for clinical therapy to fit pharmacodynamic parameters with S-(-)-VPM concentration replacing total VPM concentration as administrated by different route." @default.
- W2359353667 created "2016-06-24" @default.
- W2359353667 creator A5053429013 @default.
- W2359353667 date "1999-01-01" @default.
- W2359353667 modified "2023-09-23" @default.
- W2359353667 title "EVALUATION OF PHARMACODYNAMICS COMBINED ENANTIOSELECTIVE PHARMACOKINETICS OF RACEMIC VERAPAMIL ADMINISTERED BY MOUTH AND INTRAVENOUS INFUSION" @default.
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